They could be a sign that your tire is developing a leak (or worse, that it's nearly ready to blow out).
• Bulges and Blisters – When the outer surface of the tire begins to weaken, it can result in a bulge or blister that extends outward from the rest of the surface. This weak spot can cause a sudden blow out. Don't put yourself, your passengers
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• Excessive Vibration - Too much vibration is almost always a sign that something is wrong. There can be a number of causes--your tires are misaligned or unbalanced, your shock absorbers are starting to go, or that there's some sort of internal problem in the tire itself.